EJN:研究称体内水分含量影响心血管健康
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2016年3月3日讯/生物谷BIOON/根据一项新的研究发表在《European Journal of Nutrition》期刊上的文章表示，轻度的脱水也会损害血管功能，这几乎与抽一支烟对血管功能的损害效果一样。
本研究表明，体内水分含量——即便是对健康的年轻男性来说，轻度的脱水对心血管疾病的发生风险也起着非常重要的作用。
阿肯色大学运动科学项目的协调员，副教授Stavros Kavouras领导国际团队进行了这项研究。
“你在不知情的情况下轻度脱水会发生内皮损伤的损害，类似抽一支烟产生的效果，”Kavouras说。“这些变化的发生是在脱水程度不到2%的情况下，这个值是阈值，当脱水程度超过这个限值时人们开始感到口渴。”
血管内皮功能主要是血管内皮组织的膨胀和收缩， 血管内皮组织是指血管的内层。它在心血管健康方面发挥着关键的作用。动脉粥样硬化是血管弹性的丧失从而导致动脉硬化，动脉粥样硬化是一个已知的心血管疾病因素。
本研究首次发现轻微的脱水和人类心血管健康相关的内皮功能受损有密切关系。
Kavouras称， 研究小组的下一步工作是研究轻微脱水对心血管系统受损的两性病人的影响，如糖尿病或心血管疾病患者。
doi: 10.1007/s00394-016-1170-8
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The effect of hypohydration on endothelial function in young healthy adults
Giannis ArnaoutisAffiliated with Department of Nutrition and Dietetics, Harokopio University , Stavros A. Kavouras , Nikolaos Stratakis, Marita Likka, Asimina Mitrakou, Christos Papamichael, Labros S. Sidossis, Kimon Stamatelopoulos
Abstract Purpose Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. Methods Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m−2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of −2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. Results Hypohydration by −1.9 ± 0.1 % of body mass resulted in decreased plasma volume by −3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg−1 (P < 0.001). FMD as a response to hypohydration decreased by −26.8 ± 3.9 % (P < 0.05). Conclusion The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.
